APPLICATION OF RESVERATROL IN INTEGRATIVE APPROACH FOR THE TREATMENT OF DISEASES IN DOGS AND CATS

Resveratrol is a stilbenoid from a group of natural phenols. The top food sources of resveratrol include the skin of blueberries, grapes, mulberries, raspberries, and peanuts. Resveratrol is a compound that plants make to fight off microbial attackers, bacteria and fungi, as well as to withstand lack of nutrients or drought.

Resveratrol has been shown to have strong antioxidant and anti-inflammatory properties. Consumption of resveratrol was linked to a number of health benefits – protection of brain functions, high anticancer potential, reduced blood pressure, maintenance of liver metabolism, strengthening of the immune system, and lowered cholesterol.

Resveratrol has a wide variety of biological actions which can prevent the beginning of many diseases and manage their symptoms. Resveratrol can influence multiple inflammatory and non-inflammatory responses and protect organs and tissues by interacting with immune cells and Silent Information Regulator 1 (SIRT1). Resveratrol is a potential adjunct to pharmaceutical therapy due to its antiviral, antioxidant, anti-inflammatory, anti-apoptotic, cardioprotective, neuroprotective, and anticancer properties.

MAIN PHARMACOLOGICAL ACTIVITY OF RESVERATROL:

ANTIOXIDATIVE – Scavenging free radicals, modulating antioxidant enzymes, prevents oxidative stress-induced cellular damage by increasing the plasma antioxidant capacity.

ANTICANCER – Ability to inhibit carcinogenesis at multiple stages by inhibiting angiogenesis, preventing the activation of carcinogens, and induction of cell cycle arrest and apoptosis in tumor cells.

CARDIOPROTECTIVE – Blocks the platelet aggregation that results in ischemia and stroke, promotes vasorelaxation through multiple pathways, reduces the formation of atherosclerotic plaques, improves serum cholesterol and triglyceride concentrations.

ANTI-INFLAMMATORY – Decreases inflammation by inhibiting the activation of inflammation mediators and markers.

IMMUNOMODULATING – Exerts immune-regulatory effects on immune cells, participates in immune cells activation, improves immunologic activity against cancer cells.

NEUROPROTECTIVE – Protects the brain against damage following cerebral ischemia and cognitive dysfunction.

ANTIOBESITY – Reduces body weight and adiposity, prevents an increase in triacylglycerol concentrations.

ANTIDIABETIC – Improves glucose homeostasis, decreases insulin resistance, improves insulin secretion, and protects beta cells of pancreas.

CHART LEGEND

H – ingredient has HIGH impact on specified disease

M – ingredient has MEDIUM impact on specified disease

N – there is no data confirming the impact of the ingredient on specified disease