Curcumin

APPLICATION OF CURCUMIN IN INTEGRATIVE APPROACH FOR THE TREATMENT OF DISEASES IN DOGS AND CATS

Polyphenol curcumin is a bright yellow pigment. It is the principal curcuminoid of turmeric. Turmeric (Curcuma longa) is a member of the ginger family (Zingiberaceae).

Turmeric has long been recognized for its medicinal properties. Curcumin has been shown to target multiple signaling molecules and demonstrated activity at the cellular level with multiple health benefits. Curcumin aids in the management of oxidative stress, metabolic syndrome, hyperlipidemia, autoimmune disorders, inflammatory and neurodegenerative diseases.

MAIN PHARMACOLOGICAL ACTIVITY OF CURCUMIN:

  • ANTIOXIDATIVE – Improves systemic markers of oxidative stress. Modulates the activity of GSH, catalase, and SOD enzymes active in the neutralization of free radicals. Inhibits ROS-generating enzymes such as lipoxygenase/cyclooxygenase and xanthine hydrogenase/oxidase.
  • ANTI-INFLAMMATORY – Capable to suppress inflammation through many different mechanisms.
  • ANTIVIRAL – Antiviral activity against papillomavirus (HPV), infectious hepatitis, adenoviruses, influenza and other respiratory viruses.
  • ANTICANCER – Prevents carcinogenesis by affecting two primary processes: angiogenesis and tumor growth.
  • ANTIBACTERIAL, ANTIFUNGAL – Inhibits growth of a variety of periodontopathic bacteria, pathogenic bacteria (E.coli, S.aureus, H.pylori), able to control fungal related spoilage and fungal pathogens.
  • ANTIALLERGIC – Regulates airway inflammation and airway obstruction mainly by modulating cytokine levels.
  • IMMUNOMODULATING – Immunosuppressive activities resulting in improvement of symptoms of rheumatoid arthritis.
  • LIPID LOWERING, ANTIDIABETIC – Improves overall function of beta-cells, lowering level of HOMA-IR (insulin resistance index). Shown significant improvements in BMI, body fat and body measures.
  • NEUROPROTECTIVE – Beneficial effects against neurodegenerative diseases.
  • CHART LEGEND

    H – ingredient has HIGH impact on specified disease

    M – ingredient has MEDIUM impact on specified disease

    N – there is no data confirming the impact of the ingredient on specified disease