APPLICATION OF QUERCETIN IN INTEGRATIVE APPROACH FOR THE TREATMENT OF DISEASES IN DOGS AND CATS

Quercetin is a pigment, plant flavonol from the flavonoid group of polyphenols. Quercetin is found in many fruits, vegetables, leaves, seeds, and grains – apples, onions, parsley, berries, red wine, green tea, and other. Quercetin is one of the most abundant flavonoids in the diet and the most extensively studied one. Quercetin is a safe, natural antioxidant and can be used in human food and animal feed.

Numerous studies have shown that quercetin has a wide range of biological actions, such as anti-carcinogenic, anti-inflammatory, hepatoprotective, renoprotective, and antiviral. Quercetin can also attenuate lipid peroxidation, platelet aggregation and capillary permeability.

Quercetin has broad-spectrum antimicrobial properties and can be used in the treatment and prevention of serious infectious bacterial diseases and reduce the use of antibiotics.

MAIN PHARMACOLOGICAL ACTIVITY OF QUERCETIN:

ANTIOXIDATIVE – Directly scavenging free radicals, chelating metal ions and inhibiting lipid peroxidation, regulating levels of glutathione to enhance antioxidant capacity, increasing expression of antioxidant enzymes glutathione transferase and aldo-keto reductase.

ANTIMICROBAL – Good inhibitory effect on the growth of pathogenic bacteria: Aspergillus flavus, Escherichia coli, Proteus, Pseudomonas aeruginosa, Salmonella enteritidis, Staphylococcus aureus.

ANTIPROTOZOAL – Inhibitory effects against various protozoan parasites: Toxoplasma, Babesia, Theileria, Trypanosoma, and Leishmania.

ANTIVIRAL – Strong antiviral activity towards a wide range of viruses.

ANTI-INFLAMMATORY – Significant anti-inflammatory potential in different cell types.

IMMUNOMODULATING – Enhancing cellular and humoral immune functions.

HEPATOPROTECTIVE – Quercetin increasing heme oxygenase 1 activity by lowering plasma concentrations of alanine aminotransferase and stimulating its hepatotoxic and hepatoprotective activity.

NEUROPROTECTIVE – Beneficial effects against neurodegenerative diseases with inhibitory effect against acetylcholinesterase and oxidative stress.

RENOPROTECTIVE – The anti-oxalate effect due to the ability to regulate the Na-K-CI transport system, renin production, natriuresis, the balance of important minerals, especially phosphorus, the filtration of toxins, salts and esters of oxalic acid.

CHART LEGEND

H – ingredient has HIGH impact on specified disease

M – ingredient has MEDIUM impact on specified disease

N – there is no data confirming the impact of the ingredient on specified disease