APPLICATION OF GABA IN INTEGRATIVE APPROACH FOR THE TREATMENT OF DISEASES IN DOGS AND CATS

GABA (Gamma-Aminobutyric acid) is the chief inhibitory neurotransmitter in the central nervous system of humans and animals. The principal role of GABA is to reduce neuronal excitability and provide a protective and calming effects throughout the nervous system.

GABA is present in animals, microorganisms, and plants. There are many food sources of GABA, especially in fermented foods. GABA as “generally recognized as safe” (GRAS status).

MAIN PHARMACOLOGICAL ACTIVITY OF GABA:

NEUROPROTECTIVE – Alleviates the severity of epileptic seizures, changes the neuron excitability in neurodegenerative diseases, protects neurons against death induced by ischemia/reperfusion, improves blood circulation in the brain, activates energy processes, increases respiratory activity of tissues, improves glucose utilization and removal of toxic metabolic products.

ANTI-INSOMNIAC – Improves nighttime hormone secretion, discontinuing sleep, and sleeplessness.

PSYCHOPROTECTIVE – Exerts antidepressant and stress-reducing effects, modulates different forms of anxiety, fears, phobias, and depression.

CARDIOPROTECTIVE – Reduces blood pressure through its antihypertensive effects, regulation of cardiovascular functions through modulating hypercholesterolemia.

ANTICANCER – Inhibits the metastasis and progression of cancer cells.

ANTIDIABETIC – Reduces hyperglycemia, increases insulin secretion, improves impaired glucose tolerance.

IMMUNOMODULATING – Modifies immune’s cell proliferation, modulates the immune response to infections, activation or suppression of cytokine secretion.

CHART LEGEND

H – ingredient has HIGH impact on specified disease

M – ingredient has MEDIUM impact on specified disease

N – there is no data confirming the impact of the ingredient on specified disease