S-Adenosylmethionine (SAMe)

S-Adenosylmethionine (SAMe)
Image of S-Adenosylmethionine (SAMe) | C15H23N6O5S+ | Supreme Pharmavet
Chemical FormulaC15H23N6O5S+
Molecular weight399.446 g/mol
Names and Identifiers
PubChem Link
Traditional NameS-Adenosylmethionine (SAMe)
CAS Registry Number29908-03-0


S-Adenosyl methionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC SAM was first discovered by Giulio Cantoni in 1952.

In bacteria, SAM-e is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis. In eukaryotic cells, SAM-e serves as a regulator of a variety of processes including DNA, tRNA, and rRNA methylation; immune response; amino acid metabolism; transsulfuration; and more. In plants, SAM-e is crucial to the biosynthesis of ethylene, an important plant hormone and signaling molecule.

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