Image of L-Сitrulline | C6H13N3O3 | Supreme Pharmavet
Chemical FormulaC6H13N3O3
Molecular weight175.188 g/mol
Names and Identifiers
PubChem Link
Traditional NameL-Сitrulline
CAS Registry Number627-77-0


The organic compound citrulline is an α-amino acid. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated in 1914 by Koga and Odake. It was finally identified by Wada in 1930. It has the formula H2NC(O)NH(CH2)3CH(NH2)CO2H. It is a key intermediate in the urea cycle, the pathway by which mammals excrete ammonia by converting it into urea. Citrulline is also produced as a byproduct of the enzymatic production of nitric oxide from the amino acid arginine, catalyzed by nitric oxide synthase.

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