Image of Isosilibinin | C25H22O10 | Supreme Pharmavet
Chemical FormulaC25H22O10
Molecular weight482.441 g/mol
Names and Identifiers
PubChem Link
Traditional NameIsosilibinin, SILYMARIN, Silibinin
CAS Registry Number22888-70-6, 65666-07-1


Silibinin (INN), also known as silybin (both from Silybum, the generic name of the plant from which it is extracted), is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin, and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. The mixture exhibits a number of pharmacological effects, particularly in the liver, and there is some clinical evidence for the use of silibinin as a supportive element in alcoholic and child grade ‘A’ liver cirrhosis.


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