|Molecular weight||384.648 g/mol|
|Names and Identifiers|
|Traditional Name||Cholecalciferol, vitamin D3, colecalciferol|
|CAS Registry Number||67-97-0|
Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin, found in some foods, and taken as a dietary supplement. It is used to treat and prevent vitamin D deficiency and associated diseases, including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. It is usually taken by mouth.
Excessive doses can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Normal doses are safe in pregnancy. It may not be effective in people with severe kidney disease.
Cholecalciferol is made in the skin following UVB light exposure. It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase the uptake of calcium by the intestines. It is found in food such as some fish, cheese, and eggs. Certain foods such as milk have cholecalciferol added to them in some countries.