Image of Beta-Caryophyllene | C15H24 | Supreme Pharmavet
Chemical FormulaC15H24
Molecular weight204.357 g/mol
Names and Identifiers
PubChem Link
Traditional NameBeta-Caryophyllene
CAS Registry Number87-44-5


Caryophyllene, or (−)-β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum (cloves), the essential oil of Cannabis sativa, rosemary, and hops. It is usually found as a mixture with isocaryophyllene (the cis double bond isomer) and α-humulene (obsolete name: α-caryophyllene), a ring-opened isomer. Caryophyllene is notable for having a cyclobutane ring, as well as a trans-double bond in a 9-membered ring, both rarities in nature.

The first total synthesis of caryophyllene in 1964 by E.J. Corey was considered one of the classic demonstrations of the possibilities of synthetic organic chemistry at the time.

Caryophyllene is one of the chemical compounds that contributes to the aroma of black pepper.


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